953-32 Controlled Hypoventilation Increases Pulmonary Vascular Resistance at the Expense of Increased Right Ventricular Work and Oxygen Consumption
نویسندگان
چکیده
منابع مشابه
Pulmonary vascular mechanics: important contributors to the increased right ventricular afterload of pulmonary hypertension.
Chronic hypoxia causes pulmonary vasoconstriction and vascular remodelling, which lead to hypoxic pulmonary hypertension (HPH). Hypoxic pulmonary hypertension is associated with living at high altitudes and is a complication of many lung diseases, including chronic obstructive pulmonary disease, cystic fibrosis and obstructive sleep apnoea. Pulmonary vascular changes that occur with HPH include...
متن کاملPulmonary vascular wall stiffness: An important contributor to the increased right ventricular afterload with pulmonary hypertension
Pulmonary hypertension (PH) is associated with structural and mechanical changes in the pulmonary vascular bed that increase right ventricular (RV) afterload. These changes, characterized by narrowing and stiffening, occur in both proximal and distal pulmonary arteries (PAs). An important consequence of arterial narrowing is increased pulmonary vascular resistance (PVR). Arterial stiffening, wh...
متن کاملIncreased Red Blood Cell Stiffness Increases Pulmonary Vascular Resistance and Pulmonary Arterial Pressure.
Patients with sickle cell anemia (SCD) and pulmonary hypertension (PH) have a significantly increased risk of sudden death compared to patients with SCD alone. Sickled red blood cells (RBCs) are stiffer, more dense, more frequently undergo hemolysis, and have a sixfold shorter lifespan compared to normal RBCs. Here, we sought to investigate the impact of increased RBC stiffness, independent of ...
متن کاملPulmonary Vascular Sclerosis with Right Ventricular Failure.
A navvy charge hand, aged 34, was admitted to Addenbrooke's Hospital on November 6, 1942. In August 1942 he noticed that some of his teeth were veiy loose and tended to bleed easily, and shortly after this that he was breathless on exertion. Until then he had always been fit with no cough or breathlessness. In early October he went to the dentist, and twelve teeth were extracted under general a...
متن کاملEffect of Oxygen on Pulmonary Vascular Resistance
L OWERED concentrations of oxygen in the inspired air have been shown to produce constriction of pulmonary vessels in the cat' 2 and in human subjects.3 4 The reaction of canine pulmonary vessels to hypoxia has been studied by many workers, whose consensus appears to favor a constrictor response. However, its variability has caused LanariZubiaur and Hamilton5 to question its biologic significan...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1995
ISSN: 0735-1097
DOI: 10.1016/0735-1097(95)92289-h